Potential Micro-Magnetic Theranostic Measures COVID-19 Viral-Load with MRI

Scientists are trying to use microscopic iron devices that will take advantage of the unique physical properties of the viral capsule (capsid) to identify and inactivate the SARS-CoV-2 virus.

Drug- and vaccine-based methods of attacking the SARS-CoV-2 virus rely on chemical properties to identify the virus (for example surface antigens). These chemical properties can change when the virus mutates, rendering those therapies ineffective. An alternative method for identifying the virus would be to use the physical properties (size, shape, rigidity) of the capsid. These capsid properties make the virus easy to recognize with a microscope. Without an intact capsid, the virus cannot survive in the body.

Shape Theranostics (Rockville, MD, USA) is trying to use microscopic iron devices that will take advantage of the unique physical properties of the viral capsid to identify and inactivate the SARS-CoV-2 virus. In a newly published work, Shape Theranostics scientists have shown that the micro-devices can change MRI signals in a way that depends on viral load. These signals enabled quantitative measurement of the SARS-CoV-2 in physiological solutions. The amount of iron in these investigational products would be less than for off-the-shelf oral iron supplements. Initial preclinical studies have demonstrated no toxicity from the micro-devices.

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