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Photodynamic Therapy Kills Tumors in Mice

By HospiMedica staff writers
Posted on 22 Nov 2000
Print article
A photosensitive compound (PH-10), believed to bind to cancerous tissue cells while clearing from healthy tissue, when used with laser light or low-level radiation has resulted in complete remission of tumors in 10 of 14 mice.

The study was conducted by Photogen Technologies Inc. (Knoxville, TN, USA), an emerging cancer diagnostics and therapeutics company. The findings suggest that, in general, the noninvasive targeted drug and light treatment, or photodynamic therapy, may stimulate the immune system into fighting cancer and preventing metastasis or recurrence of cancer. New tumors did not develop in mice whose cancers had been previously treated with PH-10 and laser light. Six of eight mice with renal adenocarcinoma that had PH-10 injected into tumors demonstrated complete remission as did all mice with breast cancer who had the treatment.

"We will continue to explore the possibility that tumors treated with PH-10 could work like an autologous vaccine,” said Taffy Williams, Ph.D., president and CEO of Photogen.



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