Genetic Analysis of Milk Ducts Detects Breast Cancer

A study has found that performing a genetic analysis of cells collected from the breast milk ducts, where 95% of breast cancer originates, may allow for earlier detection of breast cancer. The study was published in the April 27,2001 issue of The Lancet .

Researchers collected cells by using ductal lavage, a minimally invasive technique that involves inserting a hair-thin microcatheter into the natural opening of the milk duct to wash out cells. After collecting breast ductal fluid, the researchers extracted DNA and used polymerase chain reaction (PCR) to amplify the DNA into quantities sufficient to visualize patterns of early breast cancer development.

The presence of abnormal cells provides biologic evidence of significantly increased, near-term breast cancer. This risk stratification is used by oncologists and breast cancer surgeons and their patients to weigh management options such as ongoing surveillance and risk-reduction drug therapy.

"Women at high risk for breast cancer and the doctors who care for them need every tool at their disposal to determine their individual biologic risks for the disease rather than relying upon population-based models,” explained David T. Hung, MD, co-author of the study and CEO of ProDuct Health (Menlo Park, CA, USA), a company focused on eradicating breast cancer through the earliest detection and treatment. "With ductal lavage, we collect cells where breast cancer originates to provide women with personalized information about their breast health.”





Related Links:
The Lancet
ProDuct Health