Chemoradiation Effective for Inoperable Head, Neck Tumors

Chemoradiation (radiation and chemotherapy given at the same time) administered through a needle or tube intravenously is as effective as treatment given directly to the tumor through a tube inserted into an artery (intra-arterial) for patients with inoperable head and neck cancer, according to a randomized study.

The study was recently presented at the plenary session November 6, 2006, at the American Society for Therapeutic Radiology and Oncology's (ASTRO) 48th Annual Meeting in Philadelphia (PA, USA). "We were surprised about the findings because previous studies that were not randomized found that intra-arterial chemoradiation was more effective than intravenous treatment,” said Coen Rasch, M.D., Ph.D., lead investigator of the study and a radiation oncologist at the Netherlands Cancer Institute/Antoni van Leeuwenhoek Huis (Amsterdam, The Netherlands). "Since intravenous chemoradiation is an easier treatment procedure for patients and doctors, it should be considered the standard of care for inoperable head and neck cancer.”

The study compared intra-arterial to intravenous chemoradiation in 240 patients with inoperable head and neck cancer, who were assigned to one of the treatment procedures by chance. The chemoradiation was a combination of radiation and cisplatin, a type of chemotherapy that can destroy cancer cells, particularly when combined with radiation. The study's findings revealed that both treatment methods were able to control the same amount of cancer growth.



Related Links:
Netherlands Cancer Institute