Mathematical Model Could Help Clinicians to Safely Allow Two COVID-19 Patients to Share Single Ventilator

Members of the University of Bath’s Centre for Therapeutic Innovation and Centre for Power Transmission and Motion Control (Bath, England) have published a first-of-its-kind research paper on dual-patient ventilation (DPV), following their work which began during the first wave of the SARS-CoV-2 virus in March 2020. DPV presents several challenges: accurate identification of patients' lung characteristics over time; close matching of patients suitable to be ventilated together, and the risk of lung damage if airflow is not safely maintained. The BathRC model enables doctors to calculate the amount of restriction required to safely ventilate two patients using one ventilator.

As a practice, DPV is strongly advised against by healthcare bodies given the potential for lung damage, and the team stresses that their findings should only be used in extreme situations where patients outnumber available equipment. No testing has been carried out on patients, instead the research so far has taken place using artificial lungs, normally used to calibrate ventilators. The model equates the ventilator circuit to an electrical circuit with resistance and compliance considered equivalent to electrical resistance and capacitance; this enabled a simple calculator to be created.

While DPV has been previously attempted during the COVID-19 pandemic, the paper is the first to provide clinicians with the calculations needed to safely ventilate two patients with one machine. The model is able to predict tidal lung volumes accurate to within 4%. In addition to further testing, some hurdles remain before clinicians could safely attempt dual-patient ventilation using the BathRC model. The team plans to publish further research soon into how to create an adjustable airflow restrictor.

"We are not advocating dual-patient ventilation, but in extreme situations in parts of the world, it may be the only option available as a last resort. The COVID-19 crisis presents a potential risk of hospitals running short of ventilators, so it is important we explore contingencies, such as how to maximize capacity," said Professor Richie Gill, Co-Vice Chair of the Centre for Therapeutic Innovation and the project's principal investigator. "This isn't something we'd envisage being needed for critical-care patients. However, one of the issues with COVID is that people can need ventilation for several weeks. If you could ventilate two recovering patients with one machine it could free up another for someone in critical need."

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