Transformational Stent Uncages the Unyielding Artery

A novel bioadaptive drug eluting stent (DES) becomes more flexible over time, allowing pulsatile motion to take over the vessel.

The Elixir Medical (Sunnyvale, CA, USA) DynamX cobalt chromium stent is a 71 microns thin cobalt-chromium DES with a thin, biodegradable polymer coating that releases Novolimus, an anti-proliferative and anti-inflammatory drug. The stent is composed of adaptive segments that are held intact by the biodegradable polymer coating, designed to absorb within six months, thus allowing the adaptive segments to uncage the stent and subsequently restore the natural pulsatile motion and adaptive remodeling of the artery.

This allows the vessel to resume arterial pulsatile motion and the Glagovian phenomenon of adaptive remodeling, which are both essential for slowing disease progression and minimizing clinical events. In clinical studies, the DynamX demonstrated significantly improved conformability and reduced torsional and longitudinal stresses compared to current drug eluting stents, thereby reducing geometric distortion of arteries and the potential for stent fractures or other clinical events.

“Elixir is committed to lead the industry to a new and exciting era with its bio-adaptive DynamX drug eluting stent,” said Motasim Sirhan, CEO of Elixir Medical. “Elixir is executing on a two-pronged strategy with bioresorbable and bioadaptive drug eluting stent to develop innovative, adaptive remodeling technologies designed to restore the normal function of arteries.”

Novolimus is an active metabolite of Sirolimus with anti-proliferative and anti-inflammatory properties. Sirolimus, in its turn, is the most widely known mammalian target of rapamycin (mTOR) macrocyclic lactone inhibitor, used in various treatment applications such as drug eluting stents, transplant, and oncology.

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