The Gazelle COVID-19 Test is portable, lightweight test detects all COVID-19 variants in 20 seconds from nasal swab samples with 99.4% accuracy compared to the gold standard, PCR. The test includes a fluorescent lateral flow immunoassay (FIA) and the Gazelle reader that utilizes image-recognition software for detection of nucleocapsid protein from SARS-CoV-2. The reader uses AI imaging and signal-to-noise enhancement techniques to achieve near-PCR accuracy.