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Integrated Syringe System Protects Highly Sensitive Compounds

By HospiMedica International staff writers
Posted on 26 Jul 2015
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Image: The Vetter-Ject syringe closure system for filling highly sensitive compounds (Photo courtesy of Vetter).
Image: The Vetter-Ject syringe closure system for filling highly sensitive compounds (Photo courtesy of Vetter).
A novel closure system for prefilled syringes comes with a ready-to-use integrated needle, offering safer use of highly-sensitive compounds such as biologics.

The Vetter-Ject syringe closure system consists of a needle hub, an integrated staked needle, and a needle shield with a tamper-evident closure system that visibly and permanently reveals attempts at opening it to the naked eye; when the needle shield is removed, the plastic bridges are broken. Complete sterile fill and final packaging of the syringe system are provided as part of the primary packaging service, including a wide range of optional stoppers, trays, and plunger rod assemblies. The company can also provide complete auto-injector assembly.

The Vetter-Ject is manufactured by means of a two-component injection molding process based on polypropylene and a thermoplastic elastomer. An individually adaptable siliconization process means less silicon oil than commonly used is necessary for coating the glass barrel, making it particularly suitable for silicon-sensitive drug products, as the amount of silicon used and the related particle load can be reduced by up to 80%, when compared to the standard siliconization process applied to conventional syringe systems. The Vetter-Ject syringe closure system is a product of Vetter (Ravensburg, Germany).

“Vetter-Ject is ready-to-use with an integrated needle that is simple to handle and user-friendly. Our patented syringe closure system offers pharmaceutical and biotech companies more options for filling highly sensitive parenteral drugs,” said Tilman Roedle, director of packaging development at Vetter. “Patients and qualified medical personnel now have the advantage of the system's easy handling and high standards for product safety and integrity.”

The siliconization of glass vials has three advantages. It minimizes the interactions between the product and container; it prevents high viscosity products from sticking to the internal surface of the vials, giving the glass bottle a prefect transparency; and due to its hydrophobic properties, the silicone coating ensures a higher restitution rate of the product. The resistance of the silicone coating depends on the chemical structure of the product formulation, as well as its dissolving power on silicone.

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